Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14646002 | 1.00 | NR1I2 (0.42) | NR1I2CYP2E1 | |
| SCHEMBL14645177 | 1.00 | NR1I2 (0.42) | NR1I2CYP2E1 | |
| SCHEMBL14718819 | 1.00 | NR1I2 (0.42) | NR1I2CYP2E1 | |
| SCHEMBL14719143 | 1.00 | NR1I2 (0.42) | NR1I2CYP2E1 | |
| SCHEMBL14645176 | 0.90 | NR1I2 (0.34) | NR1I2CYP2E1 | |
| SCHEMBL14645175 | 0.90 | NR1I2 (0.34) | NR1I2CYP2E1 | |
| SCHEMBL14645211 | 0.90 | NR1I2 (0.34) | NR1I2CYP2E1 | |
| SCHEMBL15132453 | 0.86 | NR1I2 (0.40) | NR1I2CYP2E1 | |
| SCHEMBL15130780 | 0.86 | NR1I2 (0.40) | NR1I2CYP2E1 | |
| SCHEMBL14726734 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734515-B1 | THIOPHEN-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2015-11-04 | — | — | EP | disclosed |
| US-8741946-B2 | Inhibitors of flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2014-06-03 | — | — | US | disclosed |
| EP-2734515-A1 | THIOPHEN-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2014-05-28 | — | — | EP | disclosed |
| US-20130052161-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2013-02-28 | — | — | US | disclosed |
| WO-2013010112-A1 | THIOPHEN-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2013-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130052161-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | HAVCR2, CYP2F1, CYP4F3 | NR1I2 60/4885CYP2E1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.