Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.34 |
| ▸ | ADH1B | P00325 | 1/20 | 0.34 |
| ▸ | ADH1C | P00326 | 1/20 | 0.34 |
| ▸ | ADH1A | P07327 | 1/20 | 0.34 |
| ▸ | ADH4 | P08319 | 1/20 | 0.34 |
| ▸ | ADH7 | P40394 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30892699 | 0.82 | MAPT (0.52) | TSHRMAPTLMNADNM1OPRM1 | |
| SCHEMBL7565480 | 0.82 | MAPT (0.52) | TSHRMAPTLMNADNM1OPRM1 | |
| SCHEMBL7557771 | 0.82 | MAPT (0.52) | TSHRMAPTLMNADNM1OPRM1 | |
| SCHEMBL10608053 | 0.82 | MAPT (0.52) | TSHRMAPTLMNADNM1OPRM1 | |
| SCHEMBL19026469 | 0.82 | MAPT (0.52) | TSHRMAPTLMNADNM1OPRM1 | |
| SCHEMBL24926247 | 0.82 | MAPT (0.52) | TSHRMAPTLMNADNM1OPRM1 | |
| SCHEMBL19853017 | 0.82 | MAPT (0.52) | TSHRMAPTLMNADNM1OPRM1 | |
| SCHEMBL8173118 | 0.82 | MAPT (0.52) | TSHRMAPTLMNADNM1OPRM1 | |
| SCHEMBL18725210 | 0.82 | MAPT (0.52) | TSHRMAPTLMNADNM1OPRM1 | |
| SCHEMBL16135675 | 0.82 | MAPT (0.52) | TSHRMAPTLMNADNM1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773869-B9 | MACROCYCLIC MODULATORS OF THE GHRELIN RECEPTOR | TRANZYME PHARMA INC (CA) | 2013-01-23 | — | — | EP | disclosed |