Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.51 |
| ▸ | EGFR | P00533 | 9/20 | 0.51 |
| ▸ | LCK | P06239 | 8/20 | 0.51 |
| ▸ | ITK | Q08881 | 7/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.44 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14576267 | 0.92 | BTK (0.55) | BTKEGFRLCKITKLYN | |
| SCHEMBL14576269 | 0.92 | BTK (0.55) | BTKEGFRLCKITKLYN | |
| SCHEMBL14575859 | 0.90 | BTK (0.55) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL14575862 | 0.90 | BTK (0.55) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL14576418 | 0.84 | BTK (0.57) | BTKEGFRLCKITKLYN | |
| SCHEMBL14576416 | 0.84 | BTK (0.57) | BTKEGFRLCKITKLYN | |
| SCHEMBL14575359 | 0.84 | BTK (0.56) | BTKEGFRLCKITKLYN | |
| SCHEMBL14575357 | 0.84 | BTK (0.56) | BTKEGFRLCKITKLYN | |
| SCHEMBL14576297 | 0.82 | BTK (0.58) | BTKEGFRLCKITKLYN | |
| SCHEMBL14576295 | 0.82 | BTK (0.58) | BTKEGFRLCKITKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013010136-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2013-01-17 | — | — | WO | disclosed |