Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10863112 | 0.83 | MAPT (0.44) | HMGCRCYP3A4GAAALDH1A1MEN1 | |
| SCHEMBL19463954 | 0.83 | HMGCR (0.48) | HMGCRHSD17B2CYP3A4ALDH1A1TSHR | |
| SCHEMBL30807386 | 0.80 | CYP3A4 (0.51) | CYP3A4ALDH1A1HPGDAKR1C3AKR1C2 | |
| SCHEMBL43253 | 0.80 | CYP3A4 (0.51) | CYP3A4ALDH1A1HPGDAKR1C3AKR1C2 | |
| SCHEMBL26664820 | 0.77 | HMGCR (0.46) | HMGCRHSD17B2CYP3A4ALDH1A1TSHR | |
| SCHEMBL12904365 | 0.77 | GAA (0.54) | HMGCRHSD17B2CYP3A4GAAALDH1A1 | |
| SCHEMBL19463877 | 0.76 | HMGCR (0.65) | HMGCRTSHRMAPK1ALOX5 | |
| Hydrochloric Acid SCHEMBL28274376 | 0.76 | CYP3A4 (0.65) | HMGCRCYP3A4ALDH1A1HPGDAKR1C3 | |
| SCHEMBL8159884 | 0.76 | CYP19A1 (0.40) | HSD17B2CYP3A4GAAALDH1A1TSHR | |
| SCHEMBL28962328 | 0.75 | HSD17B2 (0.45) | HMGCRHSD17B2GAAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585511-B1 | ASTHMA AND ALLERGIC INFLAMMATION MODULATORS | AMGEN INC (US) | 2013-01-23 | — | — | EP | disclosed |