Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14635106 | 0.95 | PIK3CA (0.53) | PIK3CAPIK3C3MTOR | |
| SCHEMBL14649553 | 0.90 | PIK3CA (0.47) | PIK3CAPIK3C3MTOR | |
| SCHEMBL14649533 | 0.89 | PIK3CA (0.52) | PIK3CAMTOR | |
| SCHEMBL14649534 | 0.87 | PIK3CA (0.45) | PIK3CAPIK3C3 | |
| SCHEMBL14635207 | 0.86 | PIK3CA (0.62) | PIK3CAMTOR | |
| SCHEMBL14635455 | 0.86 | PIK3CA (0.52) | PIK3CAPIK3C3MTOR | |
| SCHEMBL14649563 | 0.85 | PIK3CA (0.45) | PIK3CAPIK3C3 | |
| SCHEMBL12466736 | 0.83 | PIK3CA (0.58) | PIK3CAMTOR | |
| SCHEMBL14649549 | 0.83 | MTOR (0.55) | PIK3CAMTOR | |
| SCHEMBL14635754 | 0.82 | PIK3CA (0.52) | PIK3CAPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466162-B2 | 5-alkynyl-pyridines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-18 | — | — | US | disclosed |
| US-20130023533-A1 | NEW 5-ALKYNYL-PYRIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023533-A1 | NEW 5-ALKYNYL-PYRIDINES | PIK3CA, MKI67, PIK3CD | PIK3CA 1/4885PIK3C3 129/4885MTOR 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.