Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14642570 | 0.85 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CGPIK3CDPIK3C3 | |
| SCHEMBL14652533 | 0.84 | PIK3CG (0.47) | PIK3CAPIK3CBPIK3CGPIK3CDPIK3C3 | |
| SCHEMBL14652463 | 0.83 | PIK3CA (0.44) | PIK3CAPIK3CBPIK3CGPIK3CDPIK3C3 | |
| SCHEMBL14642583 | 0.81 | PIK3CA (0.68) | PIK3CAPIK3C3GHSR | |
| SCHEMBL14652529 | 0.81 | PIK3C3 (0.45) | PIK3CAPIK3CBPIK3CGPIK3CDPIK3C3 | |
| SCHEMBL14652548 | 0.80 | SLC22A12 (0.43) | PIK3CAPIK3CGPIK3C3GHSR | |
| SCHEMBL14652545 | 0.80 | PIK3CA (0.43) | PIK3CAPIK3CGPIK3C3 | |
| SCHEMBL14652577 | 0.78 | PIK3CA (0.44) | PIK3CAPIK3CGPIK3C3 | |
| SCHEMBL14642263 | 0.78 | PIK3CA (0.70) | PIK3CAPIK3CBPIK3CGPIK3CDPIK3C3 | |
| SCHEMBL12466420 | 0.78 | PIK3CA (0.70) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023519-A1 | 5-ALKYNYL-PYRIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-01-24 | — | — | US | disclosed |
| US-20130023533-A1 | NEW 5-ALKYNYL-PYRIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023519-A1 | 5-ALKYNYL-PYRIDINES | PIK3CA, PTEN, PIK3CD | PIK3CA 1/4885PIK3CB 7/4885PIK3CG 6/4885 |
| US-20130023533-A1 | NEW 5-ALKYNYL-PYRIDINES | PIK3CA, MKI67, PIK3CD | PIK3CA 1/4885PIK3CB 4/4885PIK3CG 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.