Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6417751 | 0.87 | GRM5 (0.38) | DPP4DPP7GRM3GRM5NPC1 | |
| SCHEMBL22826051 | 0.83 | DPP4 (0.44) | DPP4DPP7CA12CA1CA2 | |
| SCHEMBL5794923 | 0.81 | DPP4 (0.41) | DPP4DPP7CA12CA1CA2 | |
| SCHEMBL5794922 | 0.81 | DPP4 (0.41) | DPP4DPP7CA12CA1CA2 | |
| SCHEMBL18615557 | 0.79 | DPP4 (0.40) | DPP4DPP7 | |
| SCHEMBL20893428 | 0.79 | DPP4 (0.40) | DPP4DPP7 | |
| SCHEMBL13451855 | 0.79 | DPP4 (0.40) | DPP4DPP7 | |
| SCHEMBL14655504 | 0.76 | DPP4 (0.41) | DPP4DPP7CA12CA1CA2 | |
| SCHEMBL50397 | 0.76 | — | — | |
| SCHEMBL524422 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |