Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 17/20 | 0.51 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869246 | 0.93 | EIF2AK3 (0.48) | EIF2AK3EIF2AK1CYP11B1CYP11B2RIPK1 | |
| SCHEMBL6926794 | 0.91 | EIF2AK3 (0.60) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL14655630 | 0.82 | EIF2AK3 (0.61) | EIF2AK3EIF2AK1CYP11B1CYP11B2EIF2AK2 | |
| SCHEMBL14655668 | 0.81 | EIF2AK3 (0.60) | EIF2AK3EIF2AK1CYP11B1CYP11B2RIPK1 | |
| SCHEMBL14576841 | 0.80 | EIF2AK3 (0.67) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL868362 | 0.79 | EIF2AK3 (0.63) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL869247 | 0.78 | EIF2AK3 (0.39) | EIF2AK3EIF2AK1CYP11B1CYP11B2RIPK1 | |
| SCHEMBL868994 | 0.76 | EIF2AK3 (0.73) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL13860336 | 0.75 | EIF2AK3 (0.67) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL869039 | 0.74 | EIF2AK3 (0.68) | EIF2AK3RIPK1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |