Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 1.00 |
| ▸ | PRKDC | P78527 | 13/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 10/20 | 1.00 |
| ▸ | PIK3CB | P42338 | 10/20 | 1.00 |
| ▸ | PIK3CG | P48736 | 10/20 | 1.00 |
| ▸ | SRC | P12931 | 5/20 | 0.63 |
| ▸ | ABL1 | P00519 | 3/20 | 0.63 |
| ▸ | MTOR | P42345 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.63 |
| ▸ | HCK | P08631 | 1/20 | 0.63 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30386838 | 1.00 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30385963 | 0.84 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21048473 | 0.84 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30387188 | 0.82 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30387571 | 0.81 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30387431 | 0.81 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5136625 | 0.80 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30387215 | 0.80 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30386831 | 0.80 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5065412 | 0.80 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101506211-B | Kinase antagonists | UNIV CALIFORNIA | 2013-05-22 | — | — | CN | disclosed |
| EP-2551270-A2 | PYRAZOLOPYRMIDINE DERIVATIVES FOR USE AS PI3 KINASE ANTAGONISTS | The Regents of The University of California (US) | 2013-01-30 | — | — | EP | disclosed |
| CN-101506211-A | Kinase antagonists | UNIV CALIFORNIA (US) | 2009-08-12 | — | — | CN | disclosed |