Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 14/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173174 | 0.91 | NR1I2 (0.39) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9965167 | 0.91 | NR1I2 (0.39) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14669111 | 0.90 | RAF1 (0.37) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL12949400 | 0.83 | NR1I2 (0.41) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL12949453 | 0.81 | RAF1 (0.38) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL173100 | 0.81 | RAF1 (0.38) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL12945313 | 0.81 | RAF1 (0.38) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL12520075 | 0.81 | NR1I2 (0.40) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL12514339 | 0.80 | NR1I2 (0.48) | NR1I2 | |
| SCHEMBL9965223 | 0.80 | NR1I2 (0.48) | NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013016499-A1 | METHODS FOR PREPARATION OF THIOPHENE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-31 | — | — | WO | disclosed |