Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2027674 | 0.80 | MAPT (0.47) | MAPTKMT2AHSD17B10TSHRALDH1A1 | |
| SCHEMBL14641590 | 0.79 | KDM4E (0.53) | MAPTKMT2AHSD17B10TSHRALDH1A1 | |
| SCHEMBL12344811 | 0.78 | DAO (0.42) | MAPTKMT2ATSHRALDH1A1KDM4E | |
| SCHEMBL26281532 | 0.77 | KMT2A (0.44) | MAPTKMT2AHSD17B10TSHRALDH1A1 | |
| SCHEMBL21152503 | 0.77 | MAPT (0.44) | MAPTKMT2AHSD17B10TSHRALDH1A1 | |
| SCHEMBL381164 | 0.77 | MAPK14 (0.52) | MAPTKMT2AHSD17B10TSHRALDH1A1 | |
| SCHEMBL2730725 | 0.77 | MAPT (0.44) | MAPTKMT2AHSD17B10TSHRALDH1A1 | |
| SCHEMBL12272115 | 0.77 | MAPT (0.57) | MAPTKMT2AHSD17B10TSHRALDH1A1 | |
| SCHEMBL13545971 | 0.77 | MAPT (0.44) | MAPTKMT2AHSD17B10TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL5445499 | 0.76 | MAPK14 (0.51) | MAPTKMT2AHSD17B10TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013016501-A1 | FORMULATIONS OF THIOPHENE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-31 | — | — | WO | disclosed |