Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3511370 | 0.85 | JAK2 (0.69) | JAK2KCNH2JAK3 | |
| SCHEMBL14670303 | 0.75 | JAK2 (0.42) | JAK2KCNH2JAK3 | |
| SCHEMBL13270107 | 0.74 | JAK2 (0.71) | JAK2KCNH2JAK3 | |
| SCHEMBL3512306 | 0.73 | JAK2 (0.69) | JAK2KCNH2JAK3 | |
| SCHEMBL3509018 | 0.71 | JAK2 (0.67) | JAK2KCNH2JAK3 | |
| SCHEMBL13269885 | 0.71 | JAK2 (0.75) | JAK2KCNH2JAK3 | |
| SCHEMBL13270115 | 0.69 | JAK2 (0.78) | JAK2KCNH2JAK3 | |
| SCHEMBL3508288 | 0.69 | JAK2 (0.63) | JAK2KCNH2JAK3 | |
| SCHEMBL3510108 | 0.68 | JAK2 (0.73) | JAK2KCNH2JAK3 | |
| SCHEMBL3510153 | 0.68 | JAK2 (0.75) | JAK2KCNH2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367706-B2 | Inhibitors of janus kinases | MERCK SHARP & DOHME CORP. (US) | 2013-02-05 | — | — | US | claimed |