Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | KCNN3 | Q9UGI6 | 6/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.33 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17026690 | 0.76 | CDK2 (0.48) | PDE10ADYRK1ACDK2PIM1CCNA2 | |
| SCHEMBL1018372 | 0.73 | PDE10A (0.67) | PDE10ADYRK1ACDK2PIM1CCNA2 | |
| SCHEMBL16828091 | 0.73 | PDE10A (0.43) | PDE10ADYRK1ACDK2PIM1CCNA2 | |
| SCHEMBL13304697 | 0.72 | CCNT1 (0.49) | CDK2CCNA2CCNA1KCNN3CDK5 | |
| SCHEMBL14528858 | 0.71 | KDM5B (0.36) | PDE10ACDK2CCNE1 | |
| SCHEMBL1523747 | 0.66 | KDM4E (0.46) | PDE10ADYRK1APIM1CDK5AURKA | |
| SCHEMBL14316241 | 0.66 | CDK2 (0.46) | PDE10ADYRK1ACDK2PIM1CCNA2 | |
| SCHEMBL14679357 | 0.66 | PDE10A (0.61) | PDE10ACDK2CCNA1KCNN3KCNN1 | |
| SCHEMBL1019447 | 0.65 | PIM1 (0.67) | PDE10ADYRK1APIM1PIM3PLK3 | |
| SCHEMBL1523598 | 0.63 | FYN (0.45) | CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130029982-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INTELLIKINE, LLC (US) | 2013-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029982-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PIK3CA, PIK3CD, PIK3CB | PDE10A 455/4885DYRK1A 1783/4885CDK2 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.