Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tiotropium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 17/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 8/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.98 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.98 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.98 |
| ▸ | TSPO | P30536 | 1/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.98 |
| ▸ | HRH1 | P35367 | 1/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.98 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.98 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.98 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tiotropium SCHEMBL19581677 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL29527286 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL4589 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL8625 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL15005742 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL7607795 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL440873 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL155760 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL5448036 | 0.99 | CHRM3 (0.98) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL2231775 | 0.99 | CHRM3 (0.98) | CHRM3CHRM2CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916305-B | Multi-carrier medicament dispenser | 陆品公司 | 2025-03-21 | — | — | CN | disclosed |
| US-11969544-B2 | Inhalers and airflow adaptors therefor | NORTON (WATERFORD) LIMITED (IE) | 2024-04-30 | — | — | US | disclosed |
| US-20230270956-A1 | DOSE COUNTER ASSEMBLIES FOR MEDICAMENT DISPENSERS | Lupin Inc. (US) | 2023-08-31 | — | — | US | disclosed |
| CN-116210004-A | Dose counter assembly for a medicament dispenser | 鲁平股份有限公司 | 2023-06-02 | — | — | CN | disclosed |
| EP-4185997-A1 | DOSE COUNTER ASSEMBLIES FOR MEDICAMENT DISPENSERS | Lupin Inc. (US) | 2023-05-31 | — | — | EP | disclosed |
| EP-4169557-A1 | INHALERS AND AIRFLOW ADAPTORS THEREFOR | Norton (Waterford) Limited (IE) | 2023-04-26 | — | — | EP | disclosed |
| US-20230120431-A1 | Multi-Carrier Medicament Dispensers | Lupin Inc. | 2023-04-20 | — | — | US | disclosed |
| CN-115916305-A | Multi-carrier medicament dispenser | 陆品公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-110177592-B | Inhaler and airflow adaptor for inhaler | 诺尔顿沃特福德有限公司 | 2023-03-31 | — | — | CN | disclosed |
| EP-4126139-A1 | MULTI-CARRIER MEDICAMENT DISPENSERS | Lupin Inc. (US) | 2023-02-08 | — | — | EP | disclosed |
| EP-3568181-B1 | INHALER | NORTON WATERFORD LTD (IE) | 2022-12-14 | — | — | EP | disclosed |
| EP-1907037-B2 | MEDICAMENT DISPENSER | GLAXO GROUP LTD (GB) | 2022-09-07 | — | — | EP | disclosed |
| WO-2022020506-A1 | DOSE COUNTER ASSEMBLIES FOR MEDICAMENT DISPENSERS | Lupin Inc. (US) | 2022-01-27 | — | — | WO | disclosed |
| EP-2554184-B1 | PREVENTIVE AND/OR REMEDY FOR HAND AND FOOT SYNDROME | ONO PHARMACEUTICAL CO (JP) | 2016-10-26 | — | — | EP | disclosed |
| US-8729056-B2 | Preventive and/or therapeutic agent of hand-foot syndrome | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-05-20 | — | — | US | disclosed |
| US-20130045956-A1 | PREVENTIVE AND/OR THERAPEUTIC AGENT OF HAND-FOOT SYNDROME | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-02-21 | — | — | US | disclosed |
| EP-2554184-A1 | PREVENTIVE AND/OR REMEDY FOR HAND AND FOOT SYNDROME | ONO Pharmaceutical Co., Ltd. (JP) | 2013-02-06 | — | — | EP | disclosed |