Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.64 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.56 |
| ▸ | MST1R | Q04912 | 1/20 | 0.56 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14675570 | 1.00 | NPC1 (0.65) | NPC1MDM2TLK2PDGFRBCSNK1A1 | |
| SCHEMBL14521137 | 0.87 | NPC1 (0.61) | NPC1MDM2TLK2PDGFRBCSNK1A1 | |
| SCHEMBL5472882 | 0.85 | MDM2 (0.72) | NPC1MDM2PDGFRBCSNK1A1NTRK1 | |
| SCHEMBL5472879 | 0.85 | MDM2 (0.72) | NPC1MDM2PDGFRBCSNK1A1NTRK1 | |
| SCHEMBL14448957 | 0.85 | MDM2 (0.72) | NPC1MDM2PDGFRBCSNK1A1NTRK1 | |
| SCHEMBL14674463 | 0.84 | MDM2 (0.58) | NPC1MDM2TLK2PDGFRBCSNK1A1 | |
| SCHEMBL14674464 | 0.84 | MDM2 (0.58) | NPC1MDM2TLK2PDGFRBCSNK1A1 | |
| SCHEMBL14659989 | 0.83 | MDM2 (0.59) | NPC1MDM2TLK2PDGFRBCSNK1A1 | |
| SCHEMBL14659990 | 0.83 | MDM2 (0.59) | NPC1MDM2TLK2PDGFRBCSNK1A1 | |
| SCHEMBL14679964 | 0.83 | NPC1 (0.70) | NPC1MDM2PDGFRBKDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | claimed |
| US-8877946-B2 | Benzylidene-indolinone compounds and their medical use | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-11-04 | — | — | US | disclosed |
| US-8877946-B2 | Benzylidene-indolinone compounds and their medical use | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-11-04 | — | — | US | disclosed |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | ERBB2, ABL1, IGF1R | NPC1 2370/4885MDM2 1030/4885TLK2 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.