⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15035095 | 0.92 | PAK3 (0.39) | — | |
| SCHEMBL15787923 | 0.83 | PAK3 (0.40) | — | |
| SCHEMBL15041894 | 0.80 | RIPK2 (0.41) | — | |
| SCHEMBL14681963 | 0.74 | PAK1 (0.57) | — | |
| SCHEMBL15036086 | 0.73 | SRC (0.36) | — | |
| SCHEMBL15035614 | 0.73 | PTK2 (0.41) | — | |
| SCHEMBL15041848 | 0.73 | PTK2 (0.41) | — | |
| SCHEMBL15041588 | 0.72 | PTK2 (0.41) | — | |
| SCHEMBL15036128 | 0.71 | PAK4 (0.47) | — | |
| SCHEMBL14681945 | 0.71 | PAK1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372970-B2 | 8-ethyl-6-(aryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS, INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-20130035335-A1 | 8-ETHYL-6-(ARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-02-07 | — | — | US | disclosed |