Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | RAF1 | P04049 | 5/20 | 0.45 |
| ▸ | BRAF | P15056 | 5/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1467948 | 0.90 | MAPT (0.46) | ALDH1A1MAPTHPGDHTTKDM4E | |
| SCHEMBL1467642 | 0.90 | NPSR1 (0.46) | ALDH1A1MAPTHPGDHTTKDM4E | |
| SCHEMBL1467015 | 0.86 | RAF1 (0.49) | ALDH1A1MAPTHPGDHTTKDM4E | |
| SCHEMBL2297946 | 0.85 | RAF1 (0.57) | ALDH1A1MAPTHPGDHTTKDM4E | |
| SCHEMBL1467656 | 0.83 | RAF1 (0.47) | ALDH1A1MAPTHPGDHTTKDM4E | |
| SCHEMBL1467343 | 0.83 | RAF1 (0.45) | ALDH1A1MAPTHPGDHTTKDM4E | |
| SCHEMBL1467172 | 0.82 | NPSR1 (0.46) | ALDH1A1MAPTHPGDHTTKDM4E | |
| SCHEMBL1466892 | 0.81 | RAF1 (0.66) | ALDH1A1MAPTHPGDHTTKDM4E | |
| SCHEMBL1467514 | 0.81 | RAF1 (0.50) | ALDH1A1MAPTHPGDHTTKDM4E | |
| SCHEMBL1467653 | 0.81 | MAPT (0.51) | ALDH1A1MAPTHPGDHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |
| US-8697737-B2 | Raf modulators and methods of use | EXELIXIS, INC. (US) | 2014-04-15 | — | — | US | claimed |
| US-20110071145-A1 | Raf Modulators And Methods Of Use | EXELIXIS, INC. (US) | 2011-03-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071145-A1 | Raf Modulators And Methods Of Use | BRAF, RAF1, ARAF | ALDH1A1 2219/4885MAPT 4711/4885HPGD 1817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.