Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 6/20 | 0.39 |
| ▸ | FUCA1 | P04066 | 4/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GLB1 | P16278 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PYGL | P06737 | 1/20 | 0.30 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28670729 | 1.00 | MAN1B1 (0.42) | MAN1B1GBA1FUCA1GLAGAA | |
| SCHEMBL28671488 | 1.00 | MAN1B1 (0.42) | MAN1B1GBA1FUCA1GLAGAA | |
| SCHEMBL14690437 | 1.00 | MAN1B1 (0.42) | MAN1B1GBA1FUCA1GLAGAA | |
| SCHEMBL14690436 | 1.00 | MAN1B1 (0.42) | MAN1B1GBA1FUCA1GLAGAA | |
| SCHEMBL28789212 | 0.82 | KDM4E (0.37) | MAN1B1GBA1FUCA1GLAGAA | |
| SCHEMBL28687094 | 0.82 | KDM4E (0.37) | ATM | |
| SCHEMBL28542900 | 0.82 | KDM4E (0.37) | ATM | |
| SCHEMBL28546245 | 0.82 | KDM4E (0.37) | MAN1B1GBA1FUCA1GLAGAA | |
| SCHEMBL28667409 | 0.82 | KDM4E (0.37) | MAN1B1GBA1FUCA1GLAGAA | |
| SCHEMBL28713464 | 0.82 | KDM4E (0.37) | MAN1B1GBA1FUCA1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2742039-B1 | COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE | HOFFMANN LA ROCHE (CH) | 2015-09-16 | — | — | EP | disclosed |
| EP-2742039-A1 | COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE | F. Hoffmann-La Roche AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| WO-2013020993-A1 | COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-14 | — | — | WO | disclosed |