Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.42 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.40 |
| ▸ | FLT4 | P35916 | 5/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | CCND2 | P30279 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13553481 | 0.95 | JAK2 (0.43) | JAK2BRD4JAK3JAK1BRD2 | |
| SCHEMBL14681938 | 0.86 | MAP4K3 (0.46) | JAK2BRD4JAK3JAK1BRD2 | |
| SCHEMBL14682014 | 0.79 | JAK2 (0.49) | JAK2BRD4JAK3JAK1BRD2 | |
| SCHEMBL13553699 | 0.75 | CDK4 (0.45) | JAK2BRD4JAK3JAK1BRD2 | |
| SCHEMBL15035077 | 0.75 | WEE1 (0.44) | WEE1CDK4CCND1CCND2CCND3 | |
| SCHEMBL14684875 | 0.75 | PAK4 (0.52) | JAK2BRD4JAK3JAK1BRD2 | |
| SCHEMBL13553860 | 0.74 | CDK4 (0.40) | JAK2BRD4JAK3JAK1BRD2 | |
| SCHEMBL15785217 | 0.74 | WEE1 (0.43) | WEE1CDK4CCND1CCND2CCND3 | |
| SCHEMBL15036135 | 0.73 | WEE1 (0.43) | JAK2BRD4WEE1PTK2FLT4 | |
| SCHEMBL14682091 | 0.72 | CDK4 (0.41) | JAK2BRD4JAK3JAK1BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372970-B2 | 8-ethyl-6-(aryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS, INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-8372970-B2 | 8-ethyl-6-(aryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS, INC. (US) | 2013-02-12 | — | — | US | disclosed |