Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.48 |
| ▸ | PAK3 | O75914 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13554116 | 0.90 | PKN1 (0.60) | PAK4PKN1PAK3LIMK1LIMK2 | |
| SCHEMBL13554111 | 0.83 | PKN1 (0.54) | PAK4PKN1PAK3LIMK1LIMK2 | |
| SCHEMBL13554112 | 0.82 | PKN1 (0.55) | PAK4PKN1PAK3LIMK1LIMK2 | |
| SCHEMBL13553547 | 0.81 | PAK4 (0.52) | PAK4PKN1PAK1PAK2 | |
| SCHEMBL13554002 | 0.81 | PKN1 (0.54) | PAK4PKN1PAK3LIMK1LIMK2 | |
| SCHEMBL12807689 | 0.81 | PKN1 (0.56) | PAK4PKN1PAK3LIMK1LIMK2 | |
| SCHEMBL14684869 | 0.80 | PAK1 (0.66) | PAK4PKN1PAK3PAK1PAK2 | |
| SCHEMBL13553548 | 0.80 | PKN1 (0.59) | PAK4PKN1PAK3LIMK1LIMK2 | |
| SCHEMBL13553545 | 0.80 | PAK4 (0.50) | PAK4PKN1PAK3LIMK1LIMK2 | |
| SCHEMBL14681963 | 0.80 | PAK1 (0.57) | PAK4PKN1PAK3LIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372970-B2 | 8-ethyl-6-(aryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS, INC. (US) | 2013-02-12 | — | — | US | disclosed |