Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 11/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14694018 | 0.88 | MAPT (0.56) | SMN1; SMN2MAPTRAB9AMEN1KMT2A | |
| SCHEMBL4346313 | 0.83 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTRAB9AMEN1KMT2A | |
| SCHEMBL4346315 | 0.83 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTRAB9AMEN1KMT2A | |
| SCHEMBL4350524 | 0.82 | MAPT (0.79) | SMN1; SMN2MAPTRAB9AMEN1KMT2A | |
| SCHEMBL14694062 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTRAB9AMEN1KMT2A | |
| SCHEMBL14694063 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTRAB9AMEN1KMT2A | |
| SCHEMBL4347336 | 0.77 | MAPT (0.79) | SMN1; SMN2MAPTRAB9AMEN1KMT2A | |
| SCHEMBL4347335 | 0.77 | MAPT (0.79) | SMN1; SMN2MAPTRAB9AMEN1KMT2A | |
| Bromide SCHEMBL4357476 | 0.76 | MAPT (0.77) | SMN1; SMN2MAPTRAB9AMEN1KMT2A | |
| Bromide SCHEMBL4357470 | 0.76 | MAPT (0.77) | SMN1; SMN2MAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890695-B1 | USE OF 2,5-DISUBSTITUTED THIAZOL-4-ONE DERIVATIVES IN DRUGS | GRUENENTHAL GMBH (DE) | 2013-02-20 | — | — | EP | claimed |