Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | PGK1 | P00558 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30275314 | 1.00 | EGFR (0.54) | EGFRPGK1LMNAPDGFRBTSHR | |
| SCHEMBL2997470 | 0.95 | EGFR (0.50) | EGFRPGK1LMNAPDGFRBTSHR | |
| SCHEMBL16082531 | 0.85 | EGFR (0.51) | EGFRPGK1LMNAPDGFRBTSHR | |
| SCHEMBL13083345 | 0.85 | EGFR (0.51) | EGFRPGK1LMNAPDGFRBTSHR | |
| SCHEMBL25409 | 0.83 | EGFR (0.41) | EGFRLMNAALDH1A1VCAM1PDE4A | |
| SCHEMBL14579636 | 0.83 | GAA (0.43) | EGFRTSHRALDH1A1CYP3A4PDE4A | |
| SCHEMBL12488021 | 0.83 | EGFR (0.46) | EGFRALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL29719180 | 0.83 | EGFR (0.41) | EGFRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22983685 | 0.83 | EGFR (0.41) | EGFRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29719028 | 0.83 | EGFR (0.41) | EGFRLMNAALDH1A1VCAM1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354591-B | Synthesis of alkylamino quinazoline and its antineoplastic activity | 广东湛江海洋医药研究院 | 2023-03-24 | — | — | CN | disclosed |
| CN-113354591-A | Synthesis of alkylamino quinazoline and its antineoplastic activity | 广东湛江海洋医药研究院 | 2021-09-07 | — | — | CN | disclosed |
| CN-107674059-B | Benzaheteroaromatic ring compound and preparation method and application thereof | 中国药科大学 | 2020-04-14 | — | — | CN | disclosed |
| EP-3103799-A1 | QUINAZOLINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2016-12-14 | — | — | EP | disclosed |
| EP-2163546-B1 | Quinazoline derivatives | PFIZER PROD INC (US) | 2016-06-01 | — | — | EP | disclosed |
| WO-2014145512-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-09-18 | — | — | WO | disclosed |
| EP-2248806-B1 | Quinazoline derivatives as tyrosine kinase inhibitors | SHANGHAI ALLIST PHARMACEUTICALS INC (CN) | 2013-04-24 | — | — | EP | disclosed |
| CN-102942561-A | 4-amino quinazoline heterocyclic compound and purpose of 4-amino quinazoline heterocyclic compound | SHENZHEN NEPTUNUS PHARMACEUTIC | 2013-02-27 | — | — | CN | disclosed |
| US-8309563-B2 | Quinazoline derivatives useful as anti-tumor medicament | SHANGHAI ALLIST PHARMACEUTICALS, INC. (CN) | 2012-11-13 | — | — | US | disclosed |
| US-8188274-B2 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-29 | — | — | US | disclosed |
| EP-0817775-A1 | QUINAZOLINE DERIVATIVES | PFIZER INC. (US) | 1998-01-14 | — | — | EP | disclosed |
| EP-0794953-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-17 | — | — | EP | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996033981-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |
| WO-1996030347-A1 | QUINAZOLINE DERIVATIVES | PFIZER INC. (US) | 1996-10-03 | — | — | WO | disclosed |
| WO-1996016960-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-06-06 | — | — | WO | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |
| US-5475001-A | Quinazoline derivatives | ZENECA LIMITED (GB) | 1995-12-12 | — | — | US | disclosed |
| WO-1995003283-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS | ZENECA LIMITED (GB) | 1995-02-02 | — | — | WO | disclosed |
| EP-0635498-A1 | Quinazoline derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | disclosed |