SCHEMBL14697219

SCHEMBL14697219

COc1ccc(CNC(=O)c2cc(-c3cccnc3Cl)cnc2-c2ccccn2)nc1OC

nearest known ligand 0.77

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 20/20 0.77
HCRTR1 O43613 18/20 0.77
CYP3A4 P08684 3/20 0.77
HTR2A P28223 1/20 0.77
HTR1A P08908 1/20 0.44
OPRM1 P35372 1/20 0.44
DRD3 P35462 1/20 0.44
HTR2B P41595 1/20 0.44
KCNH2 Q12809 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mk-1064 SCHEMBL30593431 0.87 HCRTR2 (1.00) HCRTR2HCRTR1CYP3A4HTR2AHTR1A
Mk-1064 SCHEMBL3486358 0.87 HCRTR2 (1.00) HCRTR2HCRTR1CYP3A4HTR2AHTR1A
SCHEMBL3486353 0.84 HCRTR2 (0.83) HCRTR2HCRTR1CYP3A4HTR2A
SCHEMBL3486920 0.84 HCRTR2 (0.83) HCRTR2HCRTR1CYP3A4HTR2A
SCHEMBL3486550 0.82 HCRTR2 (0.79) HCRTR2HCRTR1CYP3A4HTR2A
SCHEMBL3487239 0.79 HCRTR2 (0.75) HCRTR2HCRTR1CYP3A4HTR2A
SCHEMBL15894168 0.79 HCRTR2 (0.85) HCRTR2HCRTR1CYP3A4HTR2AHTR1A
SCHEMBL2248733 0.76 HCRTR2 (0.84) HCRTR2HCRTR1CYP3A4HTR2A
SCHEMBL2280032 0.76 HCRTR2 (0.82) HCRTR2HCRTR1CYP3A4HTR2AHTR1A
SCHEMBL3486460 0.76 HCRTR2 (0.79) HCRTR2HCRTR1CYP3A4HTR2AHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2744481-A1 USE OF INORGANIC MATRIX AND ORGANIC POLYMER COMBINATIONS FOR PREPARING STABLE AMORPHOUS DISPERSIONS Merck Sharp & Dohme Corp. (US) 2014-06-25 EP claimed
WO-2013025449-A1 USE OF INORGANIC MATRIX AND ORGANIC POLYMER COMBINATIONS FOR PREPARING STABLE AMORPHOUS DISPERSIONS MERCK SHARP & DOHME CORP. (US) 2013-02-21 WO claimed