Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 7/20 | 0.34 |
| ▸ | PIM1 | P11309 | 4/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14699721 | 0.88 | JAK2 (0.37) | JAK2JAK3KCNH2TBK1IKBKE | |
| SCHEMBL13464977 | 0.80 | JAK2 (0.53) | JAK2JAK3KCNH2 | |
| SCHEMBL1248438 | 0.78 | JAK2 (0.43) | JAK2JAK3KCNH2TBK1IKBKE | |
| SCHEMBL1246903 | 0.78 | JAK2 (0.42) | JAK2JAK3KCNH2TBK1IKBKE | |
| SCHEMBL1248345 | 0.77 | JAK2 (0.44) | JAK2JAK3KCNH2TBK1IKBKE | |
| SCHEMBL1246898 | 0.74 | PIM1 (0.39) | JAK2JAK3KCNH2PIM1PIM3 | |
| SCHEMBL2180150 | 0.74 | JAK2 (0.47) | JAK2JAK3KCNH2 | |
| SCHEMBL1248346 | 0.72 | JAK2 (0.42) | JAK2JAK3KCNH2TBK1IKBKE | |
| SCHEMBL2178450 | 0.72 | JAK2 (0.74) | JAK2JAK3KCNH2MAPT | |
| SCHEMBL1248277 | 0.69 | JAK2 (0.44) | JAK2JAK3KCNH2TBK1IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278969-B1 | Inhibitors of Janus kinases | MERCK SHARP & DOHME (US) | 2013-02-13 | — | — | EP | disclosed |