Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 18/20 | 0.64 |
| ▸ | HTR2B | P41595 | 17/20 | 0.64 |
| ▸ | HTR2A | P28223 | 16/20 | 0.64 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10217487 | 0.92 | HTR2C (0.76) | HTR2CHTR2BHTR2A | |
| SCHEMBL10218929 | 0.88 | HTR2C (0.82) | HTR2CHTR2BHTR2AMAPKAPK2 | |
| SCHEMBL2573385 | 0.86 | HTR2C (0.73) | HTR2CHTR2BHTR2A | |
| SCHEMBL10217458 | 0.84 | HTR2C (0.70) | HTR2CHTR2BHTR2A | |
| SCHEMBL13329044 | 0.83 | HTR2C (0.73) | HTR2CHTR2BHTR2AMAPKAPK2 | |
| SCHEMBL10219027 | 0.82 | HTR2C (0.80) | HTR2CHTR2BHTR2AMAPKAPK2 | |
| SCHEMBL10217496 | 0.81 | HTR2C (0.73) | HTR2CHTR2BHTR2A | |
| SCHEMBL10218965 | 0.80 | HTR2C (0.81) | HTR2CHTR2BHTR2A | |
| SCHEMBL10217493 | 0.79 | HTR2C (0.60) | HTR2CHTR2BHTR2A | |
| SCHEMBL10216877 | 0.79 | HTR2C (0.62) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2384328-B1 | 6,7,8,9-TETRAHYDRO-5H-1,4,7,10A-TETRAAZA-CYCLOHEPT[F]INDENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM INT (DE) | 2013-02-13 | — | — | EP | disclosed |