⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5943350 | 0.73 | — | — | |
| SCHEMBL15403900 | 0.73 | — | — | |
| SCHEMBL21561430 | 0.71 | — | — | |
| SCHEMBL10049096 | 0.71 | — | — | |
| SCHEMBL1470134 | 0.69 | — | — | |
| SCHEMBL29130149 | 0.69 | — | — | |
| SCHEMBL1030811 | 0.67 | — | — | |
| SCHEMBL1469466 | 0.67 | — | — | |
| SCHEMBL1030810 | 0.67 | — | — | |
| SCHEMBL10346482 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230390303-A1 | CANCER TREATMENT BY COMBINATION OF EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | ONO PHARMACEUTICAL CO., LTD. (JP) | 2023-12-07 | — | — | US | disclosed |
| EP-4245301-A1 | CANCER TREATMENT BY COMBINED USE OF EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | ONO Pharmaceutical Co., Ltd. (JP) | 2023-09-20 | — | — | EP | disclosed |
| US-20220048881-A1 | TRICYCLIC SPIRO COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2022-02-17 | — | — | US | disclosed |
| US-11192876-B2 | Tricyclic spiro compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-12-07 | — | — | US | disclosed |
| EP-3482760-B1 | COMBINATION COMPRISING EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | ONO PHARMACEUTICAL CO (JP) | 2021-11-10 | — | — | EP | disclosed |
| US-11065226-B2 | Combination comprising EP4 antagonist and immune checkpoint inhibitor | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-07-20 | — | — | US | disclosed |
| EP-3778562-A1 | TRICYCLIC SPIRO COMPOUND | ONO Pharmaceutical Co., Ltd. (JP) | 2021-02-17 | — | — | EP | disclosed |
| US-20200102284-A1 | TRICYCLIC SPIRO COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2020-04-02 | — | — | US | disclosed |
| US-10538502-B2 | Tricyclic spiro compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2020-01-21 | — | — | US | disclosed |
| US-20190255013-A1 | COMBINATION COMPRISING EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | ONO PHARMACEUTICAL CO., LTD. (JP) | 2019-08-22 | — | — | US | disclosed |
| CN-102208681-A | Nonaqueous electrolyte solution and lithium secondary battery using same | MITSUBISHI CHEM CORP | 2011-10-05 | — | — | CN | disclosed |
| US-8007938-B2 | Nonaqueous electrolyte solution and lithium secondary battery using same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2011-08-30 | — | — | US | disclosed |
| CN-101609911-B | Nonaqueous electrolyte solution and lithium secondary battery using same | MITSUBISHI CHEM CORP | 2011-05-18 | — | — | CN | disclosed |
| US-20110070485-A1 | NONAQUEOUS ELECTROLYTE SOLUTION AND LITHIUM SECONDARY BATTERY USING SAME | MITSUBISHI CHEMICAL CORPORATION (JP) | 2011-03-24 | — | — | US | disclosed |
| CN-101894973-A | Nonaqueous electrolyte solution and lithium secondary battery using same | MITSUBISHI CHEM CORP | 2010-11-24 | — | — | CN | disclosed |
| CN-101609911-A | Nonaqueous electrolyte solution and lithium secondary battery using same | MITSUBISHI CHEM CORP (JP) | 2009-12-23 | — | — | CN | disclosed |
| CN-100544109-C | Nonaqueous electrolyte solution and lithium secondary battery using same | MITSUBISHI CHEM CORP (JP) | 2009-09-23 | — | — | CN | disclosed |
| US-20070224514-A1 | Nonaqueous Electrolyte Solution and Lithium Secondary Battery Using Same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-09-27 | — | — | US | disclosed |
| CN-1943071-A | Nonaqueous electrolyte solution and lithium secondary battery using same | MITSUBISHI CHEM CORP (JP) | 2007-04-04 | — | — | CN | disclosed |
| EP-1744394-A1 | NONAQUEOUS ELECTROLYTE SOLUTION AND LITHIUM SECONDARY BATTERY USING SAME | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-01-17 | — | — | EP | disclosed |