Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 13/20 | 0.77 |
| ▸ | PIM2 | Q9P1W9 | 13/20 | 0.77 |
| ▸ | PIM1 | P11309 | 19/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14703710 | 0.95 | PIM3 (0.69) | PIM3PIM2PIM1 | |
| SCHEMBL14703532 | 0.92 | PIM1 (0.76) | PIM3PIM2PIM1 | |
| SCHEMBL14703428 | 0.90 | PIM1 (0.77) | PIM3PIM2PIM1 | |
| SCHEMBL14703423 | 0.88 | PIM1 (0.74) | PIM3PIM2PIM1 | |
| SCHEMBL14703427 | 0.87 | PIM1 (0.69) | PIM3PIM2PIM1 | |
| SCHEMBL14705686 | 0.87 | PIM3 (1.00) | PIM3PIM2PIM1 | |
| SCHEMBL14703522 | 0.85 | PIM1 (0.70) | PIM3PIM2PIM1 | |
| SCHEMBL14703421 | 0.85 | PIM1 (0.75) | PIM3PIM2PIM1 | |
| SCHEMBL17140204 | 0.85 | PIM3 (0.55) | PIM3PIM2PIM1 | |
| Hydrochloric Acid SCHEMBL18696123 | 0.84 | PIM3 (0.55) | PIM3PIM2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2743271-B1 | PIM KINASE INHIBITORS AND PREPARATION METHOD AND USE IN MEDICINAL MANUFACTURE THEREOF | JIKAI BIOSCIENCES INC (CN) | 2017-05-31 | — | — | EP | claimed |
| US-9090594-B2 | PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof | Jikai Biosciences, Inc. (CN) | 2015-07-28 | — | — | US | claimed |
| US-20140162999-A1 | PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF | Jikai Biosciences, Inc. (CN) | 2014-06-12 | — | — | US | claimed |
| EP-2743271-B1 | PIM KINASE INHIBITORS AND PREPARATION METHOD AND USE IN MEDICINAL MANUFACTURE THEREOF | JIKAI BIOSCIENCES INC (CN) | 2017-05-31 | — | — | EP | disclosed |
| EP-2743271-B1 | PIM KINASE INHIBITORS AND PREPARATION METHOD AND USE IN MEDICINAL MANUFACTURE THEREOF | JIKAI BIOSCIENCES INC (CN) | 2017-05-31 | — | — | EP | disclosed |
| US-9090594-B2 | PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof | Jikai Biosciences, Inc. (CN) | 2015-07-28 | — | — | US | disclosed |
| US-9090594-B2 | PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof | Jikai Biosciences, Inc. (CN) | 2015-07-28 | — | — | US | disclosed |
| US-9090594-B2 | PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof | Jikai Biosciences, Inc. (CN) | 2015-07-28 | — | — | US | disclosed |
| EP-2743271-A1 | PIM KINASE INHIBITOR AND PREPARATION METHOD AND USE IN MEDICINAL MANUFACTURE THEREOF | Jikai Biosciences Inc. (CN) | 2014-06-18 | — | — | EP | disclosed |
| EP-2743271-A1 | PIM KINASE INHIBITOR AND PREPARATION METHOD AND USE IN MEDICINAL MANUFACTURE THEREOF | Jikai Biosciences Inc. (CN) | 2014-06-18 | — | — | EP | disclosed |
| US-20140162999-A1 | PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF | Jikai Biosciences, Inc. (CN) | 2014-06-12 | — | — | US | disclosed |
| US-20140162999-A1 | PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF | Jikai Biosciences, Inc. (CN) | 2014-06-12 | — | — | US | disclosed |
| US-20140162999-A1 | PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF | Jikai Biosciences, Inc. (CN) | 2014-06-12 | — | — | US | disclosed |
| WO-2013020370-A1 | PIM KINASE INHIBITOR AND PREPARATION METHOD AND USE IN MEDICINAL MANUFACTURE THEREOF | 上海吉铠医药科技有限公司 (CN) | 2013-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140162999-A1 | PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF | PIM1, PIM2, PIM3 | PIM3 3/4885PIM2 2/4885PIM1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.