Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.67 |
| ▸ | JAK2 | O60674 | 17/20 | 0.67 |
| ▸ | JAK3 | P52333 | 15/20 | 0.67 |
| ▸ | TYK2 | P29597 | 11/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14708331 | 0.91 | JAK1 (0.68) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL16477607 | 0.90 | JAK1 (0.67) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL14697497 | 0.86 | JAK1 (0.75) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL13397912 | 0.81 | JAK1 (0.66) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2274433 | 0.81 | JAK1 (1.00) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL566555 | 0.81 | JAK1 (0.74) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL565627 | 0.81 | JAK1 (0.74) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL3314386 | 0.77 | JAK1 (0.66) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL3315133 | 0.77 | JAK1 (0.66) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL13398153 | 0.77 | JAK1 (0.66) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013024895-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AND JAK INHIBITORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-02-21 | — | — | WO | disclosed |