Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | MARK4 | Q96L34 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9500170 | 0.90 | CYP1A2 (0.86) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPK1 | |
| SCHEMBL10675936 | 0.90 | CYP1A2 (1.00) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPK1 | |
| SCHEMBL10675727 | 0.89 | CYP1A2 (0.84) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPK1 | |
| SCHEMBL9498732 | 0.88 | CYP1A2 (0.78) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPK1 | |
| SCHEMBL20579814 | 0.87 | SMN1; SMN2 (0.80) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPK1 | |
| SCHEMBL21096489 | 0.87 | CYP1A2 (0.80) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPK1 | |
| SCHEMBL20579850 | 0.84 | CYP1A2 (0.75) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPK1 | |
| SCHEMBL30218495 | 0.82 | MAPK1 (0.75) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPK1 | |
| SCHEMBL9981450 | 0.81 | MAPK1 (0.62) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPK1 | |
| SCHEMBL14710304 | 0.81 | MAPT (0.61) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975235-B2 | Lysophosphatidic acid receptor antagonists | INTERMUNE, INC. (US) | 2015-03-10 | — | — | US | disclosed |
| US-8975235-B2 | Lysophosphatidic acid receptor antagonists | INTERMUNE, INC. (US) | 2015-03-10 | — | — | US | disclosed |
| US-20130072449-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072449-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. (US) | 2013-03-21 | — | — | US | disclosed |
| WO-2013025733-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. (US) | 2013-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072449-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR5 | CYP1A2 4548/4885CYP2C9 4744/4885CYP2C19 4544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.