Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 19/20 | 0.78 |
| ▸ | LPAR3 | Q9UBY5 | 5/20 | 0.78 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.78 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.44 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.44 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14709973 | 1.00 | LPAR1 (0.78) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL14710034 | 0.98 | LPAR1 (0.79) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL14788791 | 0.93 | LPAR1 (0.66) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL14711506 | 0.92 | LPAR1 (0.70) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL14709969 | 0.91 | LPAR1 (0.69) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL14712043 | 0.91 | LPAR1 (0.70) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL14710041 | 0.91 | LPAR1 (0.70) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL14788757 | 0.90 | LPAR1 (0.82) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL14711772 | 0.90 | LPAR1 (0.72) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL14709976 | 0.90 | LPAR1 (0.72) | LPAR1LPAR3LPAR2ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975235-B2 | Lysophosphatidic acid receptor antagonists | INTERMUNE, INC. (US) | 2015-03-10 | — | — | US | disclosed |
| US-8975235-B2 | Lysophosphatidic acid receptor antagonists | INTERMUNE, INC. (US) | 2015-03-10 | — | — | US | disclosed |
| WO-2013025733-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. (US) | 2013-02-21 | — | — | WO | disclosed |