Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 15/20 | 0.68 |
| ▸ | AURKA | O14965 | 2/20 | 0.68 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | PRKACG | P22612 | 1/20 | 0.49 |
| ▸ | PRKACB | P22694 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14712409 | 0.94 | ITK (0.71) | ITKAURKAPRKACAPRKACGPRKACB | |
| SCHEMBL14712507 | 0.89 | ITK (0.70) | ITKAURKAPRKACAPRKACGPRKACB | |
| SCHEMBL16165893 | 0.89 | ITK (0.72) | ITKAURKAPRKACAPRKACGPRKACB | |
| SCHEMBL14712484 | 0.88 | ITK (0.71) | ITKAURKAPRKACAPRKACGPRKACB | |
| SCHEMBL14712586 | 0.87 | ITK (0.64) | ITKAURKAPRKACAPRKACGPRKACB | |
| SCHEMBL14712590 | 0.86 | ITK (0.79) | ITKAURKAPRKACAPRKACGPRKACB | |
| SCHEMBL16165855 | 0.86 | ITK (0.74) | ITKAURKAPRKACAPRKACGPRKACB | |
| SCHEMBL14712584 | 0.86 | ITK (0.62) | ITKAURKAPRKACAPRKACGPRKACB | |
| SCHEMBL14712580 | 0.86 | ITK (0.66) | ITKAURKAPRKACAPRKACGPRKACB | |
| SCHEMBL14712588 | 0.86 | ITK (0.73) | ITKAURKAPRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013024011-A1 | INDAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-21 | — | — | WO | disclosed |