Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.57 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL833945 | 0.91 | KDR (0.59) | KDRPDGFRBGRM5 | |
| SCHEMBL835058 | 0.91 | KDR (0.65) | KDRPDGFRBGRM5 | |
| SCHEMBL15810261 | 0.90 | KDR (0.61) | KDRPDGFRBGRM5 | |
| SCHEMBL14713211 | 0.90 | KDR (0.48) | KDRPDGFRB | |
| SCHEMBL833621 | 0.89 | KDR (0.57) | KDRPDGFRB | |
| SCHEMBL833427 | 0.89 | KDR (0.47) | KDRPDGFRBKAT6A | |
| SCHEMBL836724 | 0.88 | KDR (0.59) | KDRPDGFRB | |
| SCHEMBL834998 | 0.88 | KDR (0.54) | KDRPDGFRB | |
| SCHEMBL836616 | 0.88 | KDR (0.56) | KDRPDGFRB | |
| SCHEMBL835190 | 0.88 | KDR (0.56) | KDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099757-B1 | SULFOXIMINES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| US-8383825-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2013-02-26 | — | — | US | disclosed |