Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836872 | 0.92 | KDR (0.47) | KDRPDGFRBMAPTMAPK1SLC16A3 | |
| SCHEMBL835768 | 0.92 | KDR (0.52) | KDRPDGFRBMAPTMAPK1SLC16A3 | |
| SCHEMBL836325 | 0.91 | KDR (0.46) | KDRPDGFRBMAPTMAPK1SLC16A3 | |
| SCHEMBL1477070 | 0.91 | KDR (0.48) | KDRPDGFRBMAPTMAPK1SLC16A3 | |
| SCHEMBL834756 | 0.90 | KDR (0.54) | KDRPDGFRBMAPTMAPK1SLC16A3 | |
| SCHEMBL834588 | 0.90 | KDR (0.46) | KDRPDGFRBMAPTMAPK1SLC16A3 | |
| SCHEMBL833934 | 0.89 | KDR (0.47) | KDRPDGFRBMAPTMAPK1SLC16A3 | |
| SCHEMBL835133 | 0.89 | KDR (0.47) | KDRPDGFRBMAPTMAPK1SLC16A3 | |
| SCHEMBL835378 | 0.89 | KDR (0.47) | KDRPDGFRBCA12CA1CA2 | |
| SCHEMBL834443 | 0.89 | KDR (0.45) | KDRPDGFRBMAPTMAPK1SLC16A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099757-B1 | SULFOXIMINES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| US-8383825-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2013-02-26 | — | — | US | disclosed |