Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835188 | 0.92 | KDR (0.55) | KDRPDGFRBMAPTHPGDKMT2A | |
| SCHEMBL836845 | 0.92 | KDR (0.52) | KDRPDGFRBMAPTKDM4EMEN1 | |
| SCHEMBL836264 | 0.91 | KDR (0.61) | KDRPDGFRBKDM4EMEN1ALDH1A1 | |
| SCHEMBL835109 | 0.90 | KDR (0.54) | KDRPDGFRBMAPTALDH1A1SLC16A3 | |
| SCHEMBL836381 | 0.90 | KDR (0.65) | KDRPDGFRB | |
| SCHEMBL835900 | 0.90 | KDR (0.51) | KDRPDGFRBKDM4EMEN1ALDH1A1 | |
| SCHEMBL14713182 | 0.90 | KDR (0.59) | KDRPDGFRBMAPTALDH1A1 | |
| SCHEMBL833206 | 0.90 | KDR (0.64) | KDRPDGFRBMAPT | |
| SCHEMBL833205 | 0.90 | KDR (0.64) | KDRPDGFRBMAPT | |
| SCHEMBL836681 | 0.90 | KDR (0.51) | KDRPDGFRBKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099757-B1 | SULFOXIMINES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| US-8383825-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2013-02-26 | — | — | US | disclosed |