Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.61 |
| ▸ | KDR | P35968 | 10/20 | 0.61 |
| ▸ | TEK | Q02763 | 6/20 | 0.61 |
| ▸ | JAK3 | P52333 | 5/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.61 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5494686 | 0.88 | KDR (0.62) | LCKKDRTEKJAK3MAPK14 | |
| SCHEMBL5503716 | 0.86 | LCK (0.70) | LCKKDRTEKJAK3MAPK14 | |
| SCHEMBL14715483 | 0.78 | LCK (0.52) | LCKKDRTEKJAK3MAPK14 | |
| SCHEMBL5499000 | 0.76 | LCK (1.00) | LCKKDRTEKJAK3MAPK14 | |
| SCHEMBL5498105 | 0.76 | LCK (0.79) | LCKKDRTEKJAK3MAPK14 | |
| SCHEMBL5501070 | 0.76 | LCK (0.60) | LCKKDRTEKJAK3MAPK14 | |
| SCHEMBL5497598 | 0.74 | LCK (0.86) | LCKKDRTEKJAK3MAPK14 | |
| SCHEMBL5495633 | 0.73 | LCK (0.64) | LCKKDRTEKJAK3MAPK14 | |
| SCHEMBL5498771 | 0.73 | LCK (0.60) | LCKKDRTEKJAK3MAPK14 | |
| SCHEMBL5497120 | 0.72 | LCK (0.82) | LCKKDRTEKJAK3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |