Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.54 |
| ▸ | TEK | Q02763 | 6/20 | 0.54 |
| ▸ | LCK | P06239 | 10/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.44 |
| ▸ | JAK3 | P52333 | 7/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGR | P09769 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13220159 | 0.82 | KDR (0.61) | KDRTEKLCKMAPK14JAK3 | |
| SCHEMBL13219963 | 0.81 | KDR (0.57) | KDRTEKLCKMAPK14JAK3 | |
| SCHEMBL5498971 | 0.81 | KDR (0.55) | KDRTEKLCKMAPK14JAK3 | |
| SCHEMBL14566873 | 0.81 | KDR (0.56) | KDRTEKLCKMAPK14JAK3 | |
| SCHEMBL5497128 | 0.80 | LCK (0.65) | KDRTEKLCKMAPK14JAK3 | |
| SCHEMBL13202323 | 0.78 | KDR (0.57) | KDRTEKLCKMAPK14JAK3 | |
| SCHEMBL5494389 | 0.77 | KDR (0.70) | KDRTEKLCKMAPK14JAK3 | |
| SCHEMBL5508000 | 0.75 | KDR (0.60) | KDRTEKLCKMAPK14JAK3 | |
| SCHEMBL1078497 | 0.75 | KDR (0.51) | KDRTEKLCKMAPK14JAK3 | |
| SCHEMBL5500875 | 0.75 | LCK (0.64) | KDRTEKLCKMAPK14JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |