Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.65 |
| ▸ | KDR | P35968 | 12/20 | 0.65 |
| ▸ | LCK | P06239 | 11/20 | 0.65 |
| ▸ | KIT | P10721 | 3/20 | 0.65 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.65 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.65 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500643 | 0.98 | MAPK14 (0.66) | MAPK14KDRLCKKITMAPK9 | |
| SCHEMBL5489478 | 0.98 | MAPK14 (0.66) | MAPK14KDRLCKKITMAPK9 | |
| SCHEMBL5488871 | 0.90 | MAPK14 (0.60) | MAPK14KDRLCKKITMAPK9 | |
| SCHEMBL5490415 | 0.89 | MAPK14 (0.71) | MAPK14KDRLCKKITMAPK9 | |
| SCHEMBL5501741 | 0.89 | MAPK14 (0.71) | MAPK14KDRLCKKITMAPK9 | |
| SCHEMBL5500229 | 0.88 | MAPK14 (0.61) | MAPK14KDRLCKKITMAPK9 | |
| SCHEMBL5501168 | 0.88 | MAPK14 (0.61) | MAPK14KDRLCKKITMAPK9 | |
| SCHEMBL5495506 | 0.86 | MAPK14 (0.65) | MAPK14KDRLCKKITMAPK9 | |
| SCHEMBL5497582 | 0.84 | MAPK14 (0.65) | MAPK14KDRLCKKITMAPK9 | |
| SCHEMBL5502472 | 0.84 | MAPK14 (0.65) | MAPK14KDRLCKKITMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | claimed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | claimed |