Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.51 |
| ▸ | LCK | P06239 | 14/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.51 |
| ▸ | JAK3 | P52333 | 12/20 | 0.51 |
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | TEK | Q02763 | 2/20 | 0.51 |
| ▸ | KRAS | P01116 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498060 | 0.84 | MAPK14 (0.58) | KDRLCKMAPK14JAK3BRAF | |
| SCHEMBL5503952 | 0.84 | KDR (0.53) | KDRLCKMAPK14JAK3BRAF | |
| SCHEMBL5499158 | 0.81 | KDR (0.56) | KDRLCKMAPK14JAK3BRAF | |
| SCHEMBL5498136 | 0.81 | LCK (0.64) | KDRLCKMAPK14JAK3BRAF | |
| SCHEMBL5498444 | 0.81 | KDR (0.56) | KDRLCKMAPK14JAK3BRAF | |
| SCHEMBL23745196 | 0.81 | ABL1 (0.57) | KDRLCKMAPK14JAK3BRAF | |
| SCHEMBL5494275 | 0.80 | LCK (0.66) | KDRLCKMAPK14JAK3BRAF | |
| SCHEMBL5488786 | 0.80 | LCK (0.65) | KDRLCKMAPK14JAK3BRAF | |
| SCHEMBL5493948 | 0.80 | LCK (0.78) | KDRLCKMAPK14JAK3BRAF | |
| SCHEMBL5494757 | 0.79 | LCK (0.80) | KDRLCKMAPK14JAK3BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | claimed |