Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL226867 | 0.91 | GPBAR1 (0.37) | MAPTSMN1; SMN2LMNABACE1EPHX2 | |
| SCHEMBL228102 | 0.88 | BACE1 (0.38) | MAPTBACE1EPHX2AURKAGPBAR1 | |
| SCHEMBL228101 | 0.88 | BACE1 (0.38) | MAPTBACE1EPHX2AURKAGPBAR1 | |
| SCHEMBL224405 | 0.87 | BACE1 (0.38) | MAPTSMN1; SMN2LMNABACE1EPHX2 | |
| SCHEMBL225210 | 0.86 | SMN1; SMN2 (0.46) | MAPTSMN1; SMN2LMNABACE1MEN1 | |
| SCHEMBL225214 | 0.85 | NR1H4 (0.44) | BACE1EPHX2MEN1KMT2ANR1H4 | |
| SCHEMBL223437 | 0.84 | BACE1 (0.39) | MAPTSMN1; SMN2BACE1AURKAMEN1 | |
| SCHEMBL226996 | 0.84 | KMT2A (0.44) | MAPTSMN1; SMN2BACE1MEN1KMT2A | |
| SCHEMBL226475 | 0.84 | BACE1 (0.38) | MAPTBACE1AURKAGPBAR1MEN1 | |
| SCHEMBL226476 | 0.84 | BACE1 (0.38) | MAPTBACE1AURKAGPBAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1523473-B1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2013-02-27 | — | — | EP | claimed |