Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.47 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.41 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.41 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.41 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.41 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.41 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.41 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.41 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.41 |
| ▸ | HSPH1 | Q92598 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL223628 | 0.95 | NR1H4 (0.44) | NR1H4ADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL224590 | 0.93 | NR1H4 (0.42) | NR1H4ADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL227804 | 0.92 | NR1H4 (0.41) | NR1H4ADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL225866 | 0.91 | NR1H4 (0.47) | NR1H4ADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL4485266 | 0.91 | NR1H4 (0.45) | NR1H4ADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL226732 | 0.90 | FFAR1 (0.40) | NR1H4HSPH1FFAR1ZAP70 | |
| SCHEMBL226731 | 0.90 | FFAR1 (0.40) | NR1H4HSPH1FFAR1ZAP70 | |
| SCHEMBL3676826 | 0.90 | NR1H4 (0.45) | NR1H4FFAR1EPHX2POLBPTGDR2 | |
| SCHEMBL226534 | 0.89 | NR1H4 (0.38) | NR1H4ADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL223541 | 0.88 | FFAR1 (0.43) | NR1H4FFAR1LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1523473-B1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2013-02-27 | — | — | EP | claimed |