Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 7/20 | 0.58 |
| ▸ | KDR | P35968 | 6/20 | 0.58 |
| ▸ | JAK3 | P52333 | 6/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.58 |
| ▸ | TEK | Q02763 | 3/20 | 0.58 |
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502481 | 0.91 | LCK (0.55) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5497608 | 0.90 | MAPK14 (0.60) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5498233 | 0.85 | MAPK14 (0.58) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5497069 | 0.83 | LCK (0.56) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5489506 | 0.83 | LCK (0.76) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5496648 | 0.82 | LCK (0.57) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5498173 | 0.82 | LCK (0.56) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5496972 | 0.81 | LCK (0.56) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5489113 | 0.81 | LCK (0.74) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5488850 | 0.80 | LCK (0.62) | LCKKDRJAK3MAPK14TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |