Sugi Predict

Sugi Predict / Compounds / SCHEMBL14715547

SCHEMBL14715547

SCHEMBL14715547

Cc1ccc(NC(=O)O)cc1-c1ccc2nc(N)ncc2c1

nearest known ligand 0.68

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ LCK P06239 15/20 0.68
▸ KDR P35968 9/20 0.68
▸ JAK3 P52333 9/20 0.68
▸ MAPK14 Q16539 9/20 0.68
▸ TEK Q02763 4/20 0.68
▸ BRAF P15056 2/20 0.64
▸ ABL1 P00519 3/20 0.47
▸ KIT P10721 1/20 0.46
▸ SRC P12931 1/20 0.46
▸ DDR2 Q16832 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5494016 0.93 LCK (0.78) LCKKDRJAK3MAPK14TEK
SCHEMBL5489144 0.92 LCK (0.67) LCKKDRJAK3MAPK14TEK
SCHEMBL5489006 0.92 LCK (0.67) LCKKDRJAK3MAPK14TEK
SCHEMBL5502467 0.90 LCK (0.77) LCKKDRJAK3MAPK14TEK
SCHEMBL5499129 0.89 LCK (0.76) LCKKDRJAK3MAPK14TEK
SCHEMBL5494677 0.87 ABL1 (0.66) LCKKDRJAK3MAPK14TEK
SCHEMBL5490661 0.87 LCK (0.73) LCKKDRJAK3MAPK14TEK
SCHEMBL5501487 0.85 LCK (0.63) LCKKDRJAK3MAPK14TEK
SCHEMBL5498156 0.85 LCK (0.68) LCKKDRJAK3MAPK14TEK
SCHEMBL5500366 0.85 LCK (0.68) LCKKDRJAK3MAPK14TEK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1836174-B1 ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS AMGEN INC (US) 2013-02-27 — — EP claimed