Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2519039 | 1.00 | PTPN2 (0.46) | PTPN2PTPN1POLBSMN1; SMN2CHRM2 | |
| SCHEMBL6522269 | 1.00 | PTPN2 (0.46) | PTPN2PTPN1POLBSMN1; SMN2CHRM2 | |
| SCHEMBL2515505 | 1.00 | PTPN2 (0.46) | PTPN2PTPN1POLBSMN1; SMN2CHRM2 | |
| SCHEMBL2523416 | 1.00 | PTPN2 (0.46) | PTPN2PTPN1POLBSMN1; SMN2CHRM2 | |
| SCHEMBL12211109 | 0.84 | CHRNA7 (0.38) | CHRM2CHRM4CHRM1CHRM3MAPT | |
| SCHEMBL16488549 | 0.83 | POLB (0.43) | PTPN2PTPN1POLBSMN1; SMN2CHRM2 | |
| SCHEMBL16488553 | 0.83 | POLB (0.43) | PTPN2PTPN1POLBSMN1; SMN2CHRM2 | |
| SCHEMBL3129177 | 0.81 | POLB (0.42) | PTPN2PTPN1POLBSMN1; SMN2CHRM2 | |
| SCHEMBL3941559 | 0.81 | PDGFRB (0.42) | PTPN2PTPN1POLBSMN1; SMN2MAPT | |
| SCHEMBL3117718 | 0.80 | POLB (0.41) | PTPN2PTPN1POLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240483-B1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2013-02-27 | — | — | EP | disclosed |