Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 18/20 | 0.60 |
| ▸ | KDR | P35968 | 13/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.60 |
| ▸ | JAK3 | P52333 | 11/20 | 0.60 |
| ▸ | TEK | Q02763 | 4/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715561 | 0.84 | LCK (0.67) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5489109 | 0.83 | LCK (0.70) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5498741 | 0.83 | LCK (0.54) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5488869 | 0.80 | LCK (0.73) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5495429 | 0.80 | LCK (0.73) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5498387 | 0.78 | LCK (0.69) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5503190 | 0.78 | LCK (0.72) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5503607 | 0.77 | LCK (0.68) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5492967 | 0.75 | LCK (1.00) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5491915 | 0.74 | LCK (0.85) | LCKKDRMAPK14JAK3TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |