Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.63 |
| ▸ | LCK | P06239 | 6/20 | 0.63 |
| ▸ | KDR | P35968 | 6/20 | 0.63 |
| ▸ | KIT | P10721 | 4/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.63 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.63 |
| ▸ | JAK3 | P52333 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 3/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491560 | 0.97 | MAPK14 (0.64) | MAPK14LCKKDRKITMAPK9 | |
| Bicarbonate SCHEMBL14715594 | 0.97 | MAPK14 (0.66) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL14569075 | 0.91 | MAPK14 (0.63) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5495649 | 0.90 | MAPK14 (0.62) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL14715687 | 0.89 | MAPK14 (0.64) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL14569073 | 0.89 | MAPK14 (0.63) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5488775 | 0.89 | MAPK14 (0.69) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL14724721 | 0.89 | MAPK14 (0.62) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL21416867 | 0.89 | MAPK14 (0.59) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5494682 | 0.89 | MAPK14 (0.59) | MAPK14LCKKDRKITMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | claimed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | claimed |