Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 20/20 | 0.61 |
| ▸ | HTR2A | P28223 | 17/20 | 0.61 |
| ▸ | DRD2 | P14416 | 15/20 | 0.61 |
| ▸ | HTR1A | P08908 | 4/20 | 0.61 |
| ▸ | DRD4 | P21917 | 4/20 | 0.61 |
| ▸ | HTR2B | P41595 | 4/20 | 0.61 |
| ▸ | HTR2C | P28335 | 3/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3084894 | 1.00 | DRD3 (0.61) | DRD3HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL3067778 | 0.90 | DRD3 (0.61) | DRD3HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL3093417 | 0.90 | DRD3 (0.61) | DRD3HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL3069391 | 0.88 | DRD3 (0.51) | DRD3HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL14715617 | 0.88 | DRD3 (0.51) | DRD3HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL3080642 | 0.85 | DRD3 (0.61) | DRD3HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL14715626 | 0.85 | DRD3 (0.61) | DRD3HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL14715634 | 0.85 | DRD3 (0.45) | DRD3HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL3082089 | 0.83 | DRD3 (0.55) | DRD3HTR2ADRD2HTR1A | |
| SCHEMBL230475 | 0.82 | DRD3 (0.60) | DRD3HTR2ADRD2HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |