Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 8/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.52 |
| ▸ | LCK | P06239 | 6/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.52 |
| ▸ | TEK | Q02763 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 4/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1078632 | 0.95 | FGFR1 (0.60) | DDR2FGFR1KDRLCKMAPK14 | |
| SCHEMBL1077857 | 0.90 | LCK (0.58) | DDR2FGFR1KDRLCKMAPK14 | |
| SCHEMBL1148513 | 0.87 | DDR2 (0.59) | DDR2FGFR1KDRLCKMAPK14 | |
| SCHEMBL1078032 | 0.85 | KDR (0.56) | DDR2KDRLCKMAPK14JAK3 | |
| SCHEMBL1080552 | 0.85 | LCK (0.64) | DDR2KDRLCKMAPK14JAK3 | |
| SCHEMBL1149686 | 0.85 | LCK (0.58) | DDR2FGFR1KDRLCKMAPK14 | |
| SCHEMBL1082897 | 0.84 | LCK (0.55) | DDR2FGFR1KDRLCKMAPK14 | |
| SCHEMBL1149152 | 0.84 | LCK (0.53) | DDR2FGFR1KDRLCKMAPK14 | |
| SCHEMBL1082084 | 0.83 | LCK (0.55) | DDR2FGFR1KDRLCKMAPK14 | |
| SCHEMBL1083164 | 0.83 | LCK (0.59) | DDR2KDRLCKMAPK14JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2269993-B1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |