Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ACP3 | P15309 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zinc Ion SCHEMBL14715816 | 0.96 | TDP1 (0.67) | TDP1MEN1KMT2AATML3MBTL1 | |
| Potassium Ion SCHEMBL2689841 | 0.96 | TDP1 (0.67) | TDP1MEN1KMT2AATML3MBTL1 | |
| SCHEMBL29597480 | 0.96 | TDP1 (0.67) | TDP1MEN1KMT2AATML3MBTL1 | |
| SCHEMBL1324476 | 0.96 | TDP1 (0.67) | TDP1MEN1KMT2AATML3MBTL1 | |
| SCHEMBL14715828 | 0.96 | TDP1 (0.67) | TDP1MEN1KMT2AATML3MBTL1 | |
| SCHEMBL29558892 | 0.96 | TDP1 (0.67) | TDP1MEN1KMT2AATML3MBTL1 | |
| SCHEMBL29597657 | 0.96 | TDP1 (0.67) | TDP1MEN1KMT2AATML3MBTL1 | |
| SCHEMBL29596554 | 0.96 | TDP1 (0.67) | TDP1MEN1KMT2AATML3MBTL1 | |
| SCHEMBL30774302 | 0.82 | TDP1 (0.74) | TDP1MEN1KMT2AATML3MBTL1 | |
| SCHEMBL7565966 | 0.82 | TDP1 (0.74) | TDP1MEN1KMT2AATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748244-B1 | METAL CARBOXYLATE ADDITIVES FOR THERMOPLASTICS | TOTAL PETROCHEMICALS & REFINING USA INC (US) | 2017-09-27 | — | — | EP | disclosed |
| US-9045615-B2 | Metal carboxylate additives for thermoplastics | FINA TECHNOLOGY, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| EP-2748244-A1 | METAL CARBOXYLATE ADDITIVES FOR THERMOPLASTICS | Total Petrochemicals & Refining USA, Inc. (US) | 2014-07-02 | — | — | EP | disclosed |
| US-20130053496-A1 | METAL CARBOXYLATE ADDITIVES FOR THERMOPLASTICS | CRAY VALLEY TECHNOLOGY USA, LLC (US) | 2013-02-28 | — | — | US | disclosed |
| WO-2013028485-A1 | METAL CARBOXYLATE ADDITIVES FOR THERMOPLASTICS | CRAY VALLEY TECHNOLOGY USA, LLC (US) | 2013-02-28 | — | — | WO | disclosed |