Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPFFR1 | Q9GZQ6 | 5/20 | 0.50 |
| ▸ | NPFFR2 | Q9Y5X5 | 5/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3272594 | 0.92 | CYP2D6 (0.49) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1316305 | 0.84 | OPRL1 (0.55) | CYP2D6ALDH1A1CYP3A4NPFFR1NPFFR2 | |
| SCHEMBL14728238 | 0.83 | NPFFR1 (0.64) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL20572136 | 0.83 | NPFFR1 (0.60) | CYP2D6ALDH1A1NPFFR1NPFFR2OPRK1 | |
| SCHEMBL12372531 | 0.82 | CYP2D6 (0.51) | CYP2D6ALDH1A1CYP3A4NPFFR1NPFFR2 | |
| SCHEMBL2842737 | 0.82 | NPFFR1 (0.69) | CYP2D6CYP3A4CYP2C19NPFFR1NPFFR2 | |
| SCHEMBL16915597 | 0.81 | NPFFR1 (0.57) | CYP2D6ALDH1A1NPFFR1NPFFR2OPRK1 | |
| SCHEMBL18319830 | 0.80 | NPFFR1 (0.54) | CYP2D6ALDH1A1NPFFR1NPFFR2CHRM2 | |
| SCHEMBL2281012 | 0.80 | CYP2D6 (0.50) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5149023 | 0.79 | DPP4 (0.58) | CYP2D6ALDH1A1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822688-B2 | Imidazo[1,2-a]pyridine derivative | ASTELLAS PHARMA INC. (JP) | 2014-09-02 | — | — | US | disclosed |
| EP-2565194-A1 | IMIDAZO[1,2-a]PYRIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2013-03-06 | — | — | EP | disclosed |
| US-20130053363-A1 | IMIDAZO[1,2-a]PYRIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053363-A1 | IMIDAZO[1,2-a]PYRIDINE DERIVATIVE | PDE4B, PDE4A, PDE4C | CYP2D6 2200/4885ALDH1A1 1070/4885CYP3A4 379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.