Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.50 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595137 | 0.94 | RIPK2 (0.59) | RIPK2KDRRIPK1RIPK3CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL14717722 | 0.84 | RIPK2 (0.55) | RIPK2KDRRIPK1RIPK3BRAF | |
| Trifluoroacetic Acid SCHEMBL14718166 | 0.83 | RIPK2 (0.61) | RIPK2KDRRIPK1RIPK3BRAF | |
| Trifluoroacetic Acid SCHEMBL14718222 | 0.82 | RIPK2 (0.60) | RIPK2KDRRIPK1RIPK3BRAF | |
| Trifluoroacetic Acid SCHEMBL14717807 | 0.82 | RIPK2 (0.57) | RIPK2KDRRIPK1RIPK3BRAF | |
| SCHEMBL2595855 | 0.79 | RIPK2 (0.71) | RIPK2KDRRIPK1RIPK3BRAF | |
| Trifluoroacetic Acid SCHEMBL14718765 | 0.78 | RIPK2 (0.65) | RIPK2KDRRIPK1RIPK3BRAF | |
| SCHEMBL2594634 | 0.77 | RIPK2 (0.66) | RIPK2KDRRIPK1RIPK3POLB | |
| SCHEMBL2589413 | 0.77 | RIPK2 (0.68) | RIPK2KDRRIPK1RIPK3BRAF | |
| SCHEMBL2592923 | 0.77 | RIPK2 (0.62) | RIPK2KDRRIPK1RIPK3BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160060222-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2016-03-03 | — | — | US | disclosed |
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | disclosed |
| US-20130053375-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060222-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | ABL1, MAP3K2, MAP4K2 | RIPK2 326/4885KDR 404/4885RIPK1 410/4885 |
| US-20130053375-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | ABL1, MAP3K2, MAP4K2 | RIPK2 326/4885KDR 404/4885RIPK1 410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.